Lobar distribution of cerebral microbleeds: The Rotterdam Scan Study

Objective: To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds. Design: Population-based, cross-sectional analysis. Setting: The Rotterdam Scan Study. Participants: A total of 198 persons (age range, 61-95 years) with lobar microbleeds. Main Outcome Measures: Distribution of microbleeds over different lobes. Results:Wefoundthat lobar cerebralmicrobleedsoccurred significantlymoreoften inthetemporallobe, aregionknown to be more affected in cerebral amyloid angiopathy. Conclusion: This study corroborates the presumed association of lobar microbleeds with cerebral amyloid angiopathy.