http://hdl.handle.net/1765/28104

pubmed: 19921204
scopus: 77952091413



Volumetric measurement of pulmonary nodules at low-dose chest CT: Effect of reconstruction setting on measurement variability


Article
volume 20, issue 5 pp 1180-1187.
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Objective: To assess volumetric measurement variability in pulmonary nodules detected at low-dose chest CT with three reconstruction settings. Methods: The volume of 200 solid pulmonary nodules was measured three times using commercially available semi-automated software of low-dose chest CT data-sets reconstructed with 1 mm section thickness and a soft kernel (A), 2 mm and a soft kernel (B), and 2 mm and a sharp kernel (C), respectively. Repeatability coefficients of the three measurements within each setting were calculated by the Bland and Altman method. A three-level model was applied to test the impact of reconstruction setting on the measured volume. Results: The repeatability coefficients were 8.9, 22.5 and 37.5% for settings A, B and C. Three-level analysis showed that settings A and C yielded a 1.29 times higher estimate of nodule volume compared with setting B (P=0.03). The significant interaction among setting, nodule location and morphology demonstrated that the effect of the reconstruction setting was different for different types of nodules. Low-dose CT reconstructed with 1 mm section thickness and a soft kernel provided the most repeatable volume measurement. Conclusion: A wide, nodule-type-dependent range of agreement between volume measurements with different reconstruction settings suggests strict consistency is required for serial CT studies.



Keywords


Automatically Extracted Terms
  • volume
  • nodules
  • measurement
  • reconstruction
  • setting
  • nodule
  • reconstruction settings
  • kernel
  • study
  • thickness
  • effect
  • section
  • volume measurement
  • repeatability
  • chest
  • low-dose chest ct
  • variability
  • section thickness
  • difference
  • participant


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