http://hdl.handle.net/1765/28591

pubmed: 20582941
scopus: 77955104531



Imatinib mesylate for children with dermatofibrosarcoma protuberans (DFSP)


Article
volume 55, issue 2 pp 369-373.
/ /
Repository contains one file which is not publicly available

Dermatofibrosarcoma protuberans (DFSP) is a rare malignant soft tissue tumor in children. DFSP is characterized by a specific fusion of the platelet-derived growth factor β (PDGFβ) with the collagen type 1α1 (COL1α1) gene which renders these tumors responsive to targeted therapy with tyrosine kinase inhibitors, such as imatinib mesylate, as is reported in adults. In the current report, we describe the first small pediatric DFSP series, in which response to imatinib mesylate contributed to successful treatment outcome.



Keywords




Bookmark with: