http://hdl.handle.net/1765/28695

pubmed: 20386596
scopus: 77956307100



Plasma levels of inter-α inhibitor proteins in children with acute dengue virus infection


Article
volume 5, issue 4.
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Background: Inter-α inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker. Methods and Findings: Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls. Conclusions: This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.





Automatically Extracted Terms
  • patient
  • infection
  • denv infections
  • level
  • study
  • concentration
  • range
  • plasma
  • disease
  • severity
  • inhibitor
  • dengue
  • children
  • inter-a inhibitor proteins
  • sample
  • protein
  • hospital
  • disease severity
  • denv infection
  • inter-alpha inhibitor proteins


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