The Role of SOCS3 Signaling in Ulcerative Colitis and Ulcerative Colitis-related Carcinogenesis
(De rol van SOCS3 signalering in colitis ulcerosa en colitis ulcerosa-gerelateerde carcinogenese)
2012-01-11
Doctoral Thesis
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Cytokine-signaling plays an important role in IBD. Proinflammatory cytokines like IL-6 contribute to the protection against pathogens, whereas they are also involved in chronic inflammation and are able to drive the survival and proliferation of cancer cells. Anti-inflammatory cytokines like IL-10 could help-out with the resolution of inflammation or prevent autoimmunity. On the other hand these anti-inflammatory cytokines can contribute to cancer development by inhibiting proper immune surveillance. All these effect warrant proper regulation of cytokine-signaling especially in a complex environment like the intestinal mucosa. In this thesis we focus on the role of SOCS3 the inhibitor of STAT3-signaling and its role in UC and UC-related CRC.
Financial support for printing this thesis was kindly given by: Dr. Falk Pharma Benelux B.V., Abbott B.V., Ferring B.V., UCB Pharma B.V., MSD Nederland B.V., Greiner bio-one, Pentax Nederland B.V., Dynavin GmbH, the Nederlandse Vereniging voor Gastroenterologie and the Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam
- expression
- socs 3 expression
- socs 3
- patient
- il -6
- stat 3
- relapse
- disease
- p-stat
- epithelial
- epithelial cells
- coliti
- biopsy
- uc patients
- cancer
- cytokine
- uc-crc
- chapter
- figure
- activation
