Graves’ Ophthalmopathy: A Comprehensive Role For Platelet-Derived Growth Factors
(Graves’ ophthalmopathie: een veelomvattende rol voor platelet-derived growth factors)
2012-03-07
Doctoral Thesis
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Autoimmune thyroid disorders include Graves’ disease (GD), which leads to hyperthyroidism, and Hashimoto’s thyroiditis, which leads to hypothyroidism. The incidence of autoimmune hypothyroidism is around five times higher than the incidence of autoimmune hyperthyroidism, but together these autoimmune thyroid disorders are the most common autoimmune conditions in the Western population and affect around 2-5% of the population. Estimates for the incidence of autoimmune hyperthyroidism vary considerably, but a recent review estimates an incidence of 80/100.000/year for women and 8/100.000/year for men in Caucasian populations. Graves’ disease (GD) is the most common cause of hyperthyroidism in Western and other iodine-sufficient populations, and accounts for ~80% of cases of hyperthyroidism.
The printing of this thesis has financially been supported by: Abbott B.V., Beckman Coulter Nederland B.V., Genzyme Nederland, J.E. Jurriaanse Stichting, Merck Sharpe & Dome B.V., MT-Diagnostics Netherlands B.V., Novartis Pharma B.V., Stichting Het Scholten-Cordes Fonds and Stichting Wetenschappelijk Onderzoek Oogziekenhuis
- fibroblast
- grave
- production
- tissue
- ophthalmopathy
- patient
- expression
- pdgf-bb
- disease
- thyroid
- hyaluronan
- imatinib mesylate
- receptor
- cytokine
- hyaluronan production
- factor
- imatinib
- effect
- endocrinol
- mesylate
