The devil is in the level : the role of the transcription factor GATA-1 in erythropoiesis
(Het venijn zit in de hoeveelheid : de rol van de transriptiefactor GATA-1 in erythropoiese)
2002-10-02
Doctoral Thesis
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In this thesis experiments are described, that were designed, to understand the process of red blood cell formation, better. In particular the final stages of the pathway that a stem cell has to follow to become a red blood cell. The experimental chapters are introduced by Chapter 1 of which a more simplified summary is given here, including some basic biology. The use of lab~slang has been tried to be avoided. Introduction Cells are the basic units of our body. Imagine them as little bags filled with water or better broth. These bags are not completely waterproof. The cells contain several smaller working units such as the nucleus (headquarters and control room) and the mitochondria (the power station). Many cells together form a tissue or an organ such as the skin, the liver, the heart or the blood
- erythroid
- factor
- transcription
- protein
- differentiation
- expression
- blood
- erythroid cells
- development
- ofgata
- mouse
- orkin
- blood cells
- promoter
- hematopoietic
- liver
- regulation
- defect
- progenitors
- activity
