Aging and genome maintenance: lessons from the mouse?
2003-02-28
Article
volume 299, issue 5611 pp 1355-1359.
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Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.
Keywords
- Animals
- Human
- Mice
- Syndrome
- Mutation
- Support, U.S. Gov't, P.H.S.
- EC 5.99.- (DNA Helicases)
- Transcription, Genetic
- *DNA Repair/genetics
- *DNA Damage
- Apoptosis
- *Aging/genetics
- *Genome
- 0 (Reactive Oxygen Species)
- Aging, Premature/*genetics
- Cell Aging
- DNA Helicases/genetics/metabolism
- EC 5.99.- (WRN protein, human)
- Genome, Human
- Longevity/genetics
- Reactive Oxygen Species/metabolism
- Telomere/physiology
