Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis
(Ontrafeling van de complexe genetische architectuur van menselijke lengte en osteoporose)
2012-06-01
Doctoral Thesis
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Osteoporosis is a common complex disease mostly characterized by decreased bone mineral density (BMD). In this thesis we show that hundreds of variants affect adult height and it is the same case for many other complex traits such as bone mineral density. We have applied the novel hypothesis-free approach of Genome-wide Association Study (GWAS) to identify those loci harboring at least one variant affecting these osteoporosis-related traits.
Supervisor
(promotor):
Keywords
Automatically Extracted Terms
- study
- association
- variant
- height
- fracture
- effect
- genet
- genome-wide
- meta-analysi
- osteoporosis
- analysis
- research
- sample
- individual
- table
- fracture risk
- european
- bone mineral density
- stage
- chapter
