Antigenic variation and resistance to neutralization in poliovirus type 1.
January 1985
Article
volume 229, issue 4718 pp 1090-1093.
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Mutations have been identified in variants of poliovirus, type 1 (Mahoney) on the basis of their resistance to neutralization by individual monoclonal antibodies. The phenotypes of these variants were defined in terms of antibody binding; the pattern of epitopes expressed or able to be exploited for neutralization were complex. Single amino acid changes can have distant (in terms of linear sequence) and generalized effects on the antigenic structure of poliovirus and similarly constituted virions.
Keywords
- Amino Acid Sequence
- Phenotype
- Mutation
- Antibodies, Monoclonal
- Amino Acids/analysis
- Epitopes/*analysis
- Immunity, Innate
- Poliovirus/genetics/*immunology
- Virion/immunology
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