A synthetic peptide derived from the animo acid sequence of canine parvovirus structural proteins which defines a B cell epitope and elicits antiviral antibody in BALB c mice.
January 1990
Article
volume 71 pp 2741-2745.
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Synthetic peptides, recombinant fusion proteins and mouse monoclonal antibodies were used to delineate a B cell epitope of the VP'2 structural protein of canine parvovirus (CPV). Although this epitope is not preferentially recognized in the normal antibody response to CPV, virus-specific antibodies could be induced in BALB/c mice with a synthetic peptide representing the epitope. The potential of this non-dominant B cell epitope to induce antiviral immunity in the presence of maternal CPV-specific antibodies, is discussed.
Keywords
- Animals
- Support, Non-U.S. Gov't
- Mice
- 0 (Recombinant Fusion Proteins)
- Dogs
- Mice, Inbred BALB C
- Epitopes
- 0 (Antibodies, Monoclonal)
- 0 (Viral Proteins)
- 0 (Epitopes)
- 0 (Antibodies, Viral)
- Antibodies, Monoclonal/immunology
- B-Lymphocytes/*immunology
- Antibodies, Viral/biosynthesis
- Viral Proteins/*immunology
- Parvoviridae/*immunology
- Recombinant Fusion Proteins/immunology
