http://hdl.handle.net/1765/3486




Gag- and env-specific serum antibodies in cats after natural and experimental infection with feline immunodeficiency virus.


Article
volume 39, issue 1-2 pp 153-165.
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In order to monitor the antibody response to feline immunodeficiency virus (FIV) in cats, following experimental and natural infection, enzyme-linked immunosorbent assays (ELISAs) were developed using recombinant env and gag proteins and p24-specific monoclonal antibodies. It was shown that in experimentally infected cats an env protein-specific antibody response was directly followed by a gag protein-specific response. Furthermore, an ELISA for the detection of env protein-specific serum antibodies proved more sensitive in identifying experimentally and naturally infected cats than ELISAs demonstrating gag protein-specific antibodies. It was concluded that, like in HIV infection of humans, the detection of env protein-specific serum antibodies in addition to gag protein-specific antibodies is not only an important tool in the diagnosis of the infection but also in studies concerning the pathogenesis of the disease.



Keywords


Automatically Extracted Terms
  • antibody
  • virus
  • infection
  • elisa
  • immunodeficiency virus
  • protein
  • immunodeficiency
  • serum
  • immunodeficiency virus infection
  • plate
  • assay
  • fiv infection
  • antigen
  • fiv-specific
  • e l i
  • development
  • serum samples
  • siebelink
  • sample
  • protein-specific


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