Viral replication and development of specific immunity in macaques after infection with different measles virus strains.
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Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MV) strain (MV-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngeal cells. The kinetics of the cell-associated viremia was similar in all infected animals. They developed specific serum IgM, IgG, and neutralizing antibody responses as well as MV-specific T cell-mediated immunity. Monkeys infected intratracheally or intramuscularly with the wild type MV-Edmonston or the attenuated MV-Schwartz strain showed a lower level of PBMC-associated viremia and less pronounced specific IgM responses. Nine months after infection with MV strains, all of the monkeys were protected from intratracheal reinfection with MV-BIL. This monkey model is suitable for study of new generations of vaccines and vaccination strategies for measles.
- Support, Non-U.S. Gov't
- *Disease Models, Animal
- *Macaca fascicularis
- *Virus Replication
- Immunity, Cellular
- 0 (Antibodies, Viral)
- 0 (Immunoglobulin M)
- Immunoglobulin M/biosynthesis
- 0 (Immunoglobulin G)
- Immunoglobulin G/biosynthesis
- Antibodies, Viral/biosynthesis
- Leukocytes, Mononuclear/microbiology
- Measles virus/immunology/*physiology