http://hdl.handle.net/1765/3694
pubmed: 10397529

CD4 T cells remain the major source of HIV-1 during end stage disease.


Article
volume 13, issue 9 pp 1015-1019.
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OBJECTIVE: To assess the source of HIV-1 production in lymphoid tissue biopsies from HIV-infected patients, with no prior anti-retroviral protease inhibitor treatment, with a CD4 cell count > 150 x 10(6)/l (group I) or < 50 x 10(6)/l (group II), co-infected with Mycobacterium tuberculosis or Mycobacterium avium complex. DESIGN AND METHODS: Lymphoid tissue biopsies from 11 HIV-1-infected patients, taken for diagnostic purposes, were studied by HIV-1 RNA in situ hybridization and immunohistochemistry. RESULTS: Patients of group I showed well organized granulomas, in contrast with patients of group II, in which granuloma formation was absent. HIV-1 RNA-positive cells in group I patients were found mainly around the granulomas, whereas in group II HIV-1-producing cells were confined to areas with remaining intact lymphoid tissue. Despite the abundant presence of macrophages, the productively infected HIV-1-positive cells in both groups were almost exclusively CD4 T cells. CONCLUSION: In contrast with previously published data, CD4 T cells appear to remain the major source of HIV-1 production in end-stage disease.



Keywords


Automatically Extracted Terms
  • patient
  • tissue
  • lymphoid
  • virus
  • macrophage
  • lymphoid tissue
  • infection
  • group
  • disease
  • stage
  • number
  • granuloma
  • lymphoid tissues
  • count
  • production
  • group i patients
  • 50 106/ l
  • virus production
  • rna-positive cells
  • hybridization


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