Osteoporosis from genes to phenotypes
(Ostoporose van genen tot fenotypen)
2004-11-10
Doctoral Thesis
| Related Files |
|---|
View PDF Version
(041110_Rivadeneira, Fernando.pdf, 21.5MB) |
Osteoporosis is a leading public health problem in our rapidly growing, aging population. It is a systemic skeletal disease characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Family and twin studies have shown that osteoporosis and its associated phenotypes are under strong genetic control. In addition, it has been shown than not one major locus is responsible of the susceptibility to develop osteoporosis; instead, diverse genetic and environmental factors involved with the disease have confi rmed its complex multifactorial nature.
The Departments of Internal Medicine and Epidemiology & Biostatistics of the Erasmus Medical Center, GE Healthcare Lunar Corporation, and the Dutch Society for Calcium and Bone Metabolism (NVCB) provided fi nancial support for the publication of this thesis
- fracture
- study
- women
- igf-i
- bone mineral density
- polymorphism
- geometry
- haplotype
- genotype
- osteoporosis
- bone geometry
- follow-up
- analysis
- change
- measurement
- allele
- femoral
- 192- bp allele
- rotterdam study
- estrogen
