ADDIS: A decision support system for evidence-based medicine
2012-10-15
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Clinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for aggregate clinical trial results. This is partly caused by unavailability (i) of trial data in a structured format suitable for re-analysis, and (ii) of a complete data model for aggregate level results. In this paper, we develop a unifying data model that enables the development of evidence-based decision support in the absence of a complete data model. We describe the supported decision processes and show how these are implemented in the open source ADDIS software. ADDIS enables semi-automated construction of meta-analyses, network meta-analyses and benefit-risk decision models, and provides visualization of all results.
- trial
- model
- study
- decision
- data model
- evidence
- treatment
- system
- result
- evidence synthesis
- review
- information
- analysis
- synthesis
- method
- meta-analysi
- support
- manuscript
- ac ce p
- network
