Two Sides of the Same Coin : Unravelling the role of transcription factors and miRNAs in activated monocytes, macrophages and microglia
(Two Sides of the Same Coin: Het ontrafelen van de rol van transcriptiefactoren en miRNA's in geactiveerde monocyten, macrofagen en microglia)
2012-11-07
Doctoral Thesis
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This thesis focusses on understanding the role of three transcriptions factors, namely ATF3, EGR3 and PU.1, and also microRNA-146a, involved in the activation of monocytes, macrophages and microglia in pathological conditions, which are thought to be driven – at least in part – by special inflammatory reactions. The diseases in question are severe psychiatric diseases, such as bipolar disorder, major depression, schizophrenia and postpartum psychosis and X-linked juvenile retinoschisis. In the introduction the immune cells, the diseases and the transcription factors + pathways will be introduced subsequently.
The studies were financially supported by the European Commission EU-FP7- HEALTH-F2-2008-222963 ‘MOODINFLAME’, ZonMW-TOP-91208018, The Pro Retina Foundation Germany, the German Research Foundation (DFG) and the J.E. Jurriaanse Stichting
- expression
- patient
- pu .1
- microglia
- monocyte
- macrophage
- factor
- activation
- transcription
- receptor
- disorder
- postpartum
- promoter
- dap 12
- response
- study
- chapter
- protein
- disease
- control
