Antigenic and genetic characterization of swine influenza A (H1N1) viruses isolated from pneumonia patients in The Netherlands.
2001-04-10
Article
volume 282, issue 2 pp 301-306.
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It is generally believed that pigs can serve as an intermediate host for the transmission of avian influenza viruses to humans or as mixing vessels for the generation of avian-human reassortant viruses. Here we describe the antigenic and genetic characterization of two influenza A (H1N1) viruses, which were isolated in The Netherlands from two patients who suffered from pneumonia. Both viruses proved to be antigenically and genetically similar to avian-like swine influenza A (H1N1) viruses which currently circulate in European pigs. It is concluded that European swine H1N1 viruses can infect humans directly, causing serious disease without the need for any reassortment event.
Keywords
- Male
- Animals
- Cell Line
- Adult
- Female
- Humans
- Molecular Sequence Data
- Child, Preschool
- Netherlands
- Phylogeny
- Sequence Homology, Nucleic Acid
- Hemagglutination Inhibition Tests
- *Influenza A Virus, H1N1 Subtype
- Immune Sera/immunology
- Swine/*virology
- Ferrets
- Likelihood Functions
- Influenza A virus/*genetics/*immunology/isolation & purification/metabolism
- Pneumonia, Viral/*transmission/*virology
Automatically Extracted Terms
- virus
- influenza
- /netherland
- h 1n viruses
- swine
- /swine
- swine influenza viruses
- sequence
- position
- human
- netherland
- european swine influenza
- transmission
- rimmelzwaan
- influenza viruses
- gene segments
- table
- european
- antigenic
- swine influenza
