The advantage of early recognition of HIV-infected cells by cytotoxic T lymphocytes.
2002-05-06
Article
volume 20, issue 15 pp 2011-2015.
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Accumulating evidence indicates that cytotoxic T-lymphocytes (CTL) play an important role in the clearing of primary and control of chronic human immunodeficiency virus (HIV) infection. Here, we discuss recent findings that indicate that the timing of target cell recognition critically contributes to CTL effectiveness. In this light several problems that have troubled CTL research are discussed. The use of early proteins like Tat and Rev is proposed for future vaccines design
Keywords
- Animals
- Female
- Humans
- Amino Acid Sequence
- Mice
- Time Factors
- T-Lymphocytes, Cytotoxic/*immunology
- Viral Load
- Kenya
- HIV Long-Term Survivors
- Antigen Presentation
- Cytotoxicity, Immunologic
- Immunity, Innate
- Epitopes/immunology
- HIV Infections/*immunology
- Macaca
- Viremia/immunology
- HLA Antigens/immunology
- AIDS Vaccines
- Gene Expression Regulation, Viral
- Gene Products, tat/*immunology/physiology
- HIV Antigens/genetics/immunology
- Gene Products, rev/*immunology/physiology
- HIV-1/genetics/*immunology
- Prostitution
- Simian Acquired Immunodeficiency Syndrome/immunology
- rev Gene Products, Human Immunodeficiency Virus
- tat Gene Products, Human Immunodeficiency Virus
