Absolute level of Epstein-Barr Virus (EBV) DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma.
August 2002
Article
volume 186, issue 3 pp 405-409.
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To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level.
Keywords
- Male
- Humans
- Longitudinal Studies
- Predictive Value of Tests
- Polymerase Chain Reaction
- Viral Load
- DNA, Viral/*blood
- Leukocytes, Mononuclear/virology
- Epstein-Barr Virus Infections/blood/complications/*virology
- HIV Infections/blood/complications/*virology
- HIV-1/*growth & development
- Herpesvirus 4, Human/*genetics/growth & development
- Lymphoma, AIDS-Related/blood/*virology
- Lymphoma, Non-Hodgkin/blood/*virology
Automatically Extracted Terms
- ebv load
- individual
- patient
- virus
- aids-nhl
- serum
- infection
- study
- lymphoma
- epstein-barr
- epstein-barr virus
- hiv-infected individuals
- group
- blood
- polymerase chain reaction
- progressor
- level
- follow-up
- lymphoproliferative
- disease
