Aetiology: Koch's postulates fulfilled for SARS virus
2003-05-15
Article
volume 423, issue 6937 pp 240-240.
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Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease.
Keywords
- Animals
- Time Factors
- Cercopithecus aethiops
- Pharynx/virology
- Lung/pathology/virology
- *Disease Models, Animal
- Vero Cells
- Macaca fascicularis/immunology/*virology
- Exanthema/complications
- Feces/virology
- Nasal Cavity/virology
- SARS Virus/immunology/isolation & purification/*pathogenicity/*physiology
- Severe Acute Respiratory Syndrome/complications/immunology/*pathology/*virology
- Sleep Stages
