ACE inhibitor use in patients with myocardial infarction. Summary ofevidence from clinical trials
January 1995
Article
volume 92, issue 10 pp 3132-3137.
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Experimental evidence for the beneficial effects on heart failure of chronic treatment with ACE inhibitors accumulated from early 1980 in experimental models of LV dysfunction secondary to AMI. These studies demonstrated an improvement in hemodynamics, LV remodeling, and mortality with ACE inhibitor treatment. The effect of ACE inhibitors during the acute phase of AMI was less clear, although there was evidence of protection from ischemic damage, possibly mediated by an increase in collateral coronary blood flow.
Keywords
- Humans
- Time Factors
- Myocardial Infarction/*drug therapy
- Randomized Controlled Trials as Topic
- Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
- Ventricular Dysfunction, Left/drug therapy
