Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.
January 1996
Article
volume 243 pp 465-468.
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We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.
Keywords
- Male
- Comparative Study
- Human
- Support, Non-U.S. Gov't
- Female
- Middle Aged
- Prognosis
- Alleles
- dementia
- 0 (Apolipoproteins)
- Apolipoproteins/*genetics
- Alzheimer Disease/*genetics/pathology
