Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease
January 1994
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Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia.
- Male
- Human
- Support, Non-U.S. Gov't
- Adult
- Aged
- Female
- Netherlands/epidemiology
- Risk Factors
- Middle Aged
- *Alleles
- Genotype
- Polymerase Chain Reaction
- Odds Ratio
- dementia
- Age of Onset
- Gene Frequency
- Family Health
- Genes, Dominant
- Apolipoproteins E/*genetics
- 0 (Apolipoproteins E)
- 0 (apolipoprotein E-4)
- Alzheimer Disease/epidemiology/*genetics
- publishing
- nature
- group
