The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease
1998-12-18
Article
volume 258, issue 2 pp 65-68.
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The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.
Keywords
- Human
- Support, Non-U.S. Gov't
- Middle Aged
- Genotype
- Linkage (Genetics)
- Alleles
- *Point Mutation
- dementia
- Genetic Screening
- Age of Onset
- Gene Frequency
- Linkage Disequilibrium
- *Regulatory Sequences, Nucleic Acid
- Apolipoproteins E/*genetics
- Alzheimer Disease/*epidemiology/*genetics
- 0 (Apolipoproteins E)
- *Polymorphism (Genetics)
- Chromosomes, Human, Pair 19/genetics
