Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations
1999-02-05
Article
volume 260, issue 3 pp 193-195.
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We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.
Keywords
- Human
- Support, Non-U.S. Gov't
- Aged
- Middle Aged
- Genotype
- Support, U.S. Gov't, P.H.S.
- Age of Onset
- Chromosomes, Human, Pair 17/genetics
- Apolipoproteins E/*genetics
- tau Proteins/*genetics
- 0 (Apolipoproteins E)
- Frontal lobe dementia
- 0 (tau Proteins)
- Dementia/*genetics/psychology
- Mutation, Missense/physiology
- Parkinson Disease/genetics
Automatically Extracted Terms
- mutation
- disease
- dementia
- onset
- genotype
- alzheimer
- apolipoprotein
- allele
- department
- missense
- apolipoprotein e
- university
- protein
- tau gene
- john c
- frontotemporal
- filament
- e 4 allele
- apolipoprotein e genotype
- apoe genotype