Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
2002-02-11
Article
volume 51, issue 2 pp 253-256.
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Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.
Keywords
- Male
- Human
- Support, Non-U.S. Gov't
- Adult
- Female
- Middle Aged
- EC 6. (Ligases)
- Pedigree
- Parkinson's disease
- Age of Onset
- Lod Score
- Family Health
- *Chromosomes, Human, Pair 1
- *Ubiquitin-Protein Ligases
- Parkinsonian Disorders/*genetics
- EC 6.3.2.19 (parkin protein)
- EC 6.3.2.19 (Ubiquitin-Protein Ligases)
- Ligases/genetics
