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http://hdl.handle.net/1765/5939

pubmed: 14633863



A genome-wide search for genes involved in type 2 diabetes in a recently genetically isolated population from the Netherlands


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volume 52, issue 12 pp 3001-3004.
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Multiple genes, interacting with the environment, contribute to the susceptibility to type 2 diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes in a recently genetically isolated population in the Netherlands. We identified 79 nuclear families with type 2 diabetes who were related within 13 generations and performed a 770-marker genome-wide scan search for shared founder alleles. Twenty-six markers yielded a logarithm of odds (LOD) score >0.59 (nominal P < 0.05), of which 7 reached LOD scores >1.17 (nominal P < 0.01). The strongest evidence for a type 2 diabetes locus was at marker D18S63 on chromosome 18p (LOD 2.3, P = 0.0006). This region was investigated further using additional markers. For one of these markers (D18S1105), we found a significant association with type 2 diabetes (odds ratio 6.7 [95% CI 1.5-30.7], P = 0.005 for the 97-bp allele, assuming a dominant model), which increased when limiting the analysis to patients with high BMI (12.25 [2.1-71], P = 0.003). A locus on chromosome 18p in patients with high BMI was suggested earlier by Parker et al. Our study is the first to confirm this locus.



Keywords


Automatically Extracted Terms
  • type 2 diabetes
  • diabetes
  • marker
  • patient
  • population
  • study
  • 0.005
  • allele
  • association
  • chromosome
  • locus
  • evidence
  • subject
  • table
  • region
  • genome scan
  • disease
  • value
  • score
  • netherland


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