Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)
August 2004
Article
volume 94, issue 3 pp 384-386.
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We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.
Keywords
- Male
- Comparative Study
- Human
- Age Distribution
- Cohort Studies
- Female
- Sex Distribution
- Incidence
- Prospective Studies
- Survival Analysis
- Prognosis
- *Genetic Predisposition to Disease
- Promoter Regions (Genetics)
- Proportional Hazards Models
- Risk Assessment
- Confidence Intervals
- Alleles
- Insulin-Like Growth Factor I/*genetics
- *Polymorphism (Genetics)
- 67763-96-6 (Insulin-Like Growth Factor I)
- Cardiovascular Disease
- Heart Failure, Congestive/*epidemiology/*genetics
