Modulography: elasticity imaging of atherosclerotic plaques
(Modulography: visualisatie van de elasticiteit van atherosclerotische plaques)
2006-06-21
Doctoral Thesis
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Modulography is an experimental elasticity imaging method. It has potential to become an all-in-one in vivo tool (a) for detecting vulnerable atherosclerotic coronary plaques, (b) for assessing information related to their rupture-proneness and (c) for imaging their elastic material composition. Modulography determines a cross-sectional image of the elasticity distribution (=Young's modulus) from deformation (=strain) that is processed from intravascular ultrasound (IVUS) measurements. By looking at this image, cardiologists and other researchers can directly identify and characterize soft and stiff plaque-components of thin-cap fibroatheromas and of heterogeneous plaques. As a diagnostic and pharmaceutical screening tool, Modulography may contribute to the reduction of heart attacks and strokes, which are the number-one killers in westernized societies.
Netherlands Heart Foundation
Pfizer
Merck Sharp & Dohme BV
Interuniversity Cardiology Institute of the Netherlands
Serruys, Prof. Dr. P.W.J.C. (promotor)
Bristol-Myers Squibb & Bristol-Myers Squibb MedicalImaging
Cardialysis
Dutch Technology Foundation (STW)
OrbusNeich
Novartis Pharma AG
Sanofi-Aventis
Volcano Corporation
Steen, Prof. Dr. A.W.F. van der (promotor)
- atherosclerosis
- elasticity
- vulnerable plaque
- intravascular ultrasound (IVUS)
- inverse problem
- tissue characterization
- plaque
- strain
- elastogram
- modulu
- artery
- reconstruction
- lipid
- tissue
- strain elastogram
- elastography
- ultrasound
- region
- model
- component
- method
- lipid pool
- mastik f
- catheter
- intravascular
- atherosclerotic
