Tumor Motility: Cell migration analysis and effects of EMAP-II on TNF antitumour activities
(Tumoren in beweging: Analyse van celmigratie en EMAP-II effecten op antitumour activiteiten van TNF)
2006-09-06
Doctoral Thesis
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RePub contains a preprint of the article 'TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility', The Oncologist, 11(4), pp 397-408, see: http://dx.doi.org/10.1634/theoncologist.11-4-397
The tumour itself is at least as dynamic as the fields of research aiming to understand cancer formation and optimize treatments for patients. This thesis describes experiments to study and analyse tumour motility at various levels. Cell migration was studied of tumour and endothelial cells by means of a novel migration method. Treatment of solid tumours with TNF was used to study the mechanisms of action. For EMAP-II studies from molecule to patient were performed. Mobilisation of proteins within cells and redistribution of cells within tumours was analysed.
J.E. Jurriaanse Stichting
Tebu-Bio
Boehringer Ingelheim Pharma GmbH
Eggermont, Prof. Dr. A.M.M. (promotor)
BioSource
Foundation ‘Erasmus Heelkundig Kankeronderzoek’
(SEHK).
Mrace Translational Research Fund (EMC)
Oko-Lab (www.microscopeincubator.com)
Foundation ‘Vanderes’
- emap-ii
- migration
- tumour
- tnf-r
- factor
- assay
- protein
- proemap
- tnf-r 1
- expression
- tumour cells
- treatment
- effect
- cell migration
- patient
- melanoma
- cancer
- response
- proemap /p cleavage
- growth
