Revisiting the clinical validity of multiplex genetic testing in complex diseases
January 2004
Letter To Editor
pp 585-588.
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The usefulness of genetic testing to identify high-risk patients for common multifactorial diseases is subject to debate. Optimism about the public health opportunities is counterbalanced with skepticism, since genetic factors appear to play a role in only a minority of patients with complex diseases, the number of genes involved is large, and their penetrance is incomplete (Holtzman and Marteau 2000; Vineis et al. 2001).
Keywords
Automatically Extracted Terms
- error
- haplotype
- result
- disease
- genotyping errors
- value
- testing
- genotyping
- probability
- marker
- family
- procedure
- study
- p values
- test results
- table
- hs-tdt
- genet
- ratio
- interaction
