Acromegaly: the significance of serum total and free IGF-I and IGF-binding protein-3 in diagnosis
January 1997
Article
| Related Files |
|---|
View PDF Version
(9389990.pdf, 0.3MB) |
We have studied the physiological and clinical relevance of measurements of serum total and free IGF-I and IGF-binding protein-3 (IGFBP-3) in 57 previously untreated patients with active acromegaly (32 males, 25 females; mean age 47 years) as compared with sex- and age-matched normal healthy controls. Serum total and free IGF-I, but not IGFBP-3, are suitable biochemical parameters for screening for acromegaly. In acromegalics, the mean 24 h serum GH, total IGF-I and IGFBP-3 levels tend to decrease with age. However, in our series of patients, mean 24 h serum GH levels, IGFBP-3, total and free IGF-I do not correlate with disease activity in acromegaly.
Keywords
- female
- male
- middle aged
- Biological Markers/blood
- humans
- Acromegaly/blood/*diagnosis
- Growth Hormone/blood
- Insulin-Like Growth Factor Binding Protein 3/*blood
- Insulin-Like Growth Factor I/*analysis
- aging/blood
Automatically Extracted Terms
- serum
- igf-i
- level
- igfbp
- acromegaly
- patient
- igfbp -3 levels
- igf-i levels
- igfbp -3
- endocrinology
- activity
- correlation
- journal
- disease activity
- growth
- diagnosis
- van der lely
- disease
- acromegalic
- serum igfbp -3
