Hypercalcemia in sarcoidosis
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In a 56-year-old man hypercalcaemia and kidney function impairment were the presenting symptoms of sarcoidosis. The diagnosis was supported by the finding of elevated 1,25-dihydroxyvitamin D levels and of a cluster of epithelioid macrophages in aspirated bone marrow. By exclusion of other granulomatous diseases and a favourable reaction of the hypercalcaemia and renal function to treatment with prednisone the diagnosis was confirmed. The relationship between the autonomous extrarenal production of 1,25-dihydroxyvitamin D and the hypercalcaemia is discussed.
- middle aged
- Diagnosis, Differential
- Kidney Diseases/etiology/urine
- Prednisone/therapeutic use
- Sarcoidosis/*complications/diagnosis/drug therapy