Inhibition of influenza virus replication by nitric oxide
January 1999
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Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumonia in mouse models. Here we show that replication of influenza A and B viruses in Mabin Darby canine kidney cells is severely impaired by the NO donor, S-nitroso-N-acetylpenicillamine. Reduction of productively infected cells and virus production proved to correlate with inhibition of viral RNA synthesis, indicating that NO affects an early step in the replication cycle of influenza viruses.
Keywords
- Animals
- Research Support, Non-U.S. Gov't
- Mice
- Dogs
- Influenza A virus/*physiology
- Influenza B virus/*physiology
- Nitric Oxide Donors/pharmacology
- Nitric Oxide/*physiology
- Penicillamine/analogs & derivatives/pharmacology
- S-Nitroso-N-Acetylpenicillamine
- Virus Replication/drug effects/*physiology
Automatically Extracted Terms
- virus
- influenza
- nitric
- oxide
- nitric oxide
- replication
- infection
- mdck cells
- influenza virus
- culture
- influenza viruses
- effect
- inhibition
- virol
- /netherland
- synthase
- production
- culture supernatants
- addition
- pneumonia
