Homologous recombination: from model organisms to human disease
January 2001
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Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
Keywords
- Animals
- Humans
- Research Support, Non-U.S. Gov't
- DNA Damage
- DNA-Binding Proteins/physiology
- Transcription Factors/physiology
- Rad51 Recombinase
- Models, Genetic
- BRCA2 Protein
- *Recombination, Genetic
- BRCA1 Protein/physiology
- DNA Helicases/physiology
- Neoplasm Proteins/physiology
- Neoplasms/genetics
Automatically Extracted Terms
- recombination
- protein
- genome
- rad 52
- rad 51 paralogs
- molecule
- rad 51
- yeast
- holliday junctions
- brca 2
- paralog
- resolution
- repair
- junction
- holliday
- dna damage
- brca 1
- branch migration
- single-stranded
- rad 51-accessory proteins
