The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.

Additional Metadata
Keywords HOPE, Hypothermic, Liver transplantation, Machine perfusion, Normothermic, Preservation
Persistent URL dx.doi.org/10.1016/j.bpg.2017.04.001, hdl.handle.net/1765/100037
Journal Best Practice and Research in Clinical Gastroenterology
Citation
Selten, J. (Jasmijn), Schlegel, A, de Jonge, J, & Dutkowski, P. (2017). Hypo- and normothermic perfusion of the liver: Which way to go?. Best Practice and Research in Clinical Gastroenterology. doi:10.1016/j.bpg.2017.04.001