In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

Additional Metadata
Keywords chromosome architecture, gene repression, heterochromatin, LADs, lamina-associated domains, nuclear architecture
Persistent URL dx.doi.org/10.1016/j.cell.2017.04.022, hdl.handle.net/1765/100071
Journal Cell
Citation
van Steensel, B, & Belmont, A.S. (Andrew S.). (2017). Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression. Cell (Vol. 169, pp. 780–791). doi:10.1016/j.cell.2017.04.022