18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ = 0.85–0.86, p < 0.05). Intermodality regional agreement was variable, moderate (κ = 0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement. Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT. (p = 0.31). Clinical experience and optimisation may further improve ASL-MRI's performance.

Additional Metadata
Keywords ASL-MRI, Dementia, Early stage, FDG PET-CT, Pseudo-continuous
Persistent URL dx.doi.org/10.1016/j.clinimag.2017.05.008, hdl.handle.net/1765/100092
Journal Clinical Imaging
Citation
Weyts, K, Vernooij, M.W, Steketee, R.M.E, Valkema, R, & Smits, M. (2017). Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia. Clinical Imaging, 45, 1–7. doi:10.1016/j.clinimag.2017.05.008