2017-05-30
Pharmacokinetic-guided dosing of clotting factor concentrates in bleeding disorders : towards individualization of treatment
Publication
Publication
Farmacokinetisch gestuurd doseren van stollingsfactoren in stollingsstoornissen : op weg naar geïndividualiseerde behandeling
All studies described in this thesis are part of the “OPTI-CLOT” research program on patient tailOred PharmacokineTIc (PK)-guided dosing of CLOTting factor concentrate in bleeding disorders. These are (inter)national multicenter studies which aim to implement PK-guided dosing of clotting factor replacement therapy by initiation of studies to prove the implications of PK-guided dosing, to construct perioperatie and prophylactic population PK models and to evaluate the cost-effectiveness of a PK-guided approach.
This thesis focuses on the evaluation of current dosing strategies and the feasibility of alternative, more individualized dosing based on PK-guidance using Bayesian analysis.
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, , , , | |
F.W.G. Leebeek (Frank) , R.A.A. Mathôt (Ron) , M.H. Cnossen (Marjon) | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/100100 | |
Organisation | Department of Pediatrics |
Hazendonk, C. (2017, May 30). Pharmacokinetic-guided dosing of clotting factor concentrates in bleeding disorders : towards individualization of treatment. Retrieved from http://hdl.handle.net/1765/100100 |
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4710_Hazendonk-Hendrika-Cornelia-Aantje-Maria.jpg Cover Image , 38kb | |
Stellingen-Hazendonk.pdf , 59kb |