Pelvic irradiation constitutes the primary or adjuvant treatment for a large number of both female and male cancers: Endometrial, cervical, vaginal, and vulvar cancer in females, prostate cancer in males, and colorectal, anal, and bladder cancer in both males and females. In case of extensive colorectal, anal, bladder, or vulvar cancers, radiotherapy may be given before surgery to decrease the tumor volume and following surgery in case of nonradical resection margins.