IFN-α and ribavirin were used to treat chronic HEV patients. However, failures of ribavirin treatment were observed and thereby new antiviral treatments are urgently required. The IFN pathway plays an important role in defending viral infection through the expression of ISGs, but little is known about the relation between HEV infection and IFN/ISG pathway. In this thesis, we aimed to investigate anti-HEV activities of IFN pathway and its mechanism-of-action. We first studied the anti-HEV potential of IFNs against HEV in cell culture models. Next, we mainly focused on the anti-HEV ability of many important ISGs and the mechanism-of-action of some key anti-HEV ISGs. Meanwhile, some novel mechanisms that regulate ISG transcription and their role in controlling HEV were also investigated.

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M.P. Peppelenbosch (Maikel) , Q. Pan (Qiuwei)
Erasmus University Rotterdam
The research was funded by: • Netherlands Organization for Scientific Research (NWO) • Dutch Digestive Foundation (MLDS) • Daniel den Hoed Foundation
Department of Gastroenterology & Hepatology

Xu, L. (2017, June 27). Interferon-stimulated Genes and Their Role in Controlling Hepatitis E Virus. Retrieved from http://hdl.handle.net/1765/100323