2017-06-28
Harms and benefits of prostate cancer screening and active surveillance
Publication
Publication
Gunstige en ongunstige effecten van het vroeg opsporing prostaat kanker en actief opwachten
Prostate cancer is the second most commonly diagnosed cancer and the 5th cause of cancer death worldwide. The PSA-test consists of a simple blood test which gives the value of PSA in the blood. An elevated PSA value indicates a high probability of presence of cancer, though it could also be due to unrelated causes. While prostate cancer screening may save lives, it also causes harm, since many screen-detected men are overdiagnosed and overtreated.
In this thesis I use a microsimulation model (MISCAN) adapted to prostate cancer to explore multiple avenues to make PSA-based screening worthwhile and effective. I find that prostate cancer screening should be focused on younger age groups, Active Surveillance should become the primary treatment option for low-risk men, and that personalized screening strategies should be adopted to minimize the harms of screening.
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H.J. de Koning (Harry) , E.A.M. Heijnsdijk (Eveline) | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/100333 | |
Organisation | Department of Public Health |
de Carvalho Delgado Marques, T. (2017, June 28). Harms and benefits of prostate cancer screening and active surveillance. Retrieved from http://hdl.handle.net/1765/100333 |
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Stellingen_final.pdf , 115kb | |
4734_Carvalho-Delgado-Marques-Tiago-Manuel-de.jpg Cover Image , 1mb |