BACKGROUND: We have previously reported the safety and effectiveness of sirolimus-eluting stents for the treatment of de novo coronary lesions. The present investigation explored the potential of this technology to treat in-stent restenosis. METHODS AND RESULTS: Twenty-five patients with in-stent restenosis were successfully treated with the implantation of 1 or 2 sirolimus-eluting Bx VELOCITY stents in Sao Paulo, Brazil. Nine patients received 2 stents (1.4 stents per lesion). Angiographic and volumetric intravascular ultrasound (IVUS) images were obtained after the procedure and at 4 and 12 months. All vessels were patent at the time of 12-month angiography. Angiographic late loss averaged 0.07+/-0.2 mm in-stent and -0.05+/-0.3 mm in-lesion at 4 months, and 0.36+/-0.46 mm in-stent and 0.16+/-0.42 mm in-lesion after 12 months. No patient had in-stent or stent margin restenosis at 4 months, and only one patient developed in-stent restenosis at 1-year follow-up. Intimal hyperplasia by 3-dimensional IVUS was 0.92+/-1.9 mm(3) at 4 months and 2.55+/-4.9 mm(3) after 1 year. Percent volume obstruction was 0.81+/-1.7% and 1.76+/-3.4% at the 4- and 12-month follow-up, respectively. There was no evidence of stent malapposition either acutely or in the follow-up IVUS images, and there were no deaths, stent thromboses, or repeat revascularizations. CONCLUSION: This study demonstrates the safety and the potential utility of sirolimus-eluting Bx VELOCITY stents for the treatment of in-stent restenosis.

*Stents/adverse effects, Combined Modality Therapy, Coronary Angiography, Coronary Restenosis/*drug therapy/radiography/surgery/ultrasonography, Delayed-Action Preparations, Echocardiography, Three-Dimensional, Female, Follow-Up Studies, Humans, Male, Middle aged, Pilot Projects, Recurrence/prevention & control, Sirolimus/*administration & dosage/therapeutic use
hdl.handle.net/1765/10045
Circulation (Baltimore)
Erasmus MC: University Medical Center Rotterdam

Sousa, J.E, Feres, F, Mattos, L.A, Centemero, M, Maldonado, G, Abizaid, A.S, … Abizaid, A.C. (2003). Sirolimus-eluting stent for the treatment of in-stent restenosis: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation (Baltimore), 107(1), 24–27. Retrieved from http://hdl.handle.net/1765/10045