1994-11-11
Inhibition of T3-receptor binding by Nitrofen
Publication
Publication
Biochimica et Biophysica Acta: international journal of biochemistry and biophysics , Volume 1201 - Issue 2 p. 266- 336
Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T3 to its receptor, via exposure to Nitrofen during fetal development.
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| doi.org/10.1016/0304-4165(94)90050-7, hdl.handle.net/1765/100486 | |
| Biochimica et Biophysica Acta: international journal of biochemistry and biophysics | |
| Organisation | Department of Pediatric Surgery |
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Brandsma, A., Tibboel, D., Vulto, I., de Vijlder, J., ten Have-Opbroek, A., & Wiersinga, W. (1994). Inhibition of T3-receptor binding by Nitrofen. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1201(2), 266–336. doi:10.1016/0304-4165(94)90050-7 |
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