Response by de Ridder et al to Letter Regarding Article, “PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial”

We thank Drs Noubiap and Kamtchum-Tatuene for their comments on our article. They express their concerns about the safety of short-term treatment with high-dose paracetamol, question whether the high dose of paracetamol used in PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) leads to a larger temperature reduction than a standard dose, and consider a new, larger, clinical trial of fever prevention in stroke futile. Their concerns can fortunately be refuted. [...]

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