Objectives: To describe the adaptation of a global health economic model to determine whether treatment with the angiotensin receptor neprilysin inhibitor LCZ696 is cost-effective compared with the angiotensin-converting enzyme inhibitor enalapril in adult patients with chronic heart failure with reduced left ventricular ejection fraction in the Netherlands; and to explore the effect of performing the cost-effectiveness analyses according to the new pharmacoeconomic Dutch guidelines (updated during the submission process of LCZ696), which require a value-of-information analysis and the inclusion of indirect medical costs of life-years gained. Methods: We adapted a UK model to reflect the societal perspective in the Netherlands by including travel expenses, productivity loss, informal care costs, and indirect medical costs during the life-years gained and performed a preliminary value-of-information analysis. Results: The incremental cost-effectiveness ratio obtained was €17,600 per quality-adjusted life-year (QALY) gained. This was robust to changes in most structural assumptions and across different subgroups of patients. Probability sensitivity analysis results showed that the probability that LCZ696 is cost-effective at a €50,000 per QALY threshold is 99.8%, with a population expected value of perfect information of €297,128. On including indirect medical costs of life-years gained, the incremental cost-effectiveness ratio was €26,491 per QALY gained, and LCZ696 was 99.46% cost-effective at €50,000 per QALY, with a population expected value of perfect information of €2,849,647. Conclusions: LCZ696 is cost-effective compared with enalapril under the former and current Dutch guidelines. However, the (monetary) consequences of making a wrong decision were considerably different in both scenarios.

Additional Metadata
Keywords ACE inhibitor, Cost-effectiveness analysis, Heart failure, Productivity costs
Persistent URL dx.doi.org/10.1016/j.jval.2017.05.013, hdl.handle.net/1765/100610
Journal Value in Health
Corro Ramos, I, Versteegh, M.M, de Boer, R.A. (Rudolf A.), Koenders, J.M.A. (Jolanda M.A.), Linssen, G.C.M, Meeder, H.J, & Rutten-van Mölken, M.P.M.H. (2017). Cost-Effectiveness of the Angiotensin Receptor Neprilysin Inhibitor Sacubitril/Valsartan for Patients with Chronic Heart Failure and Reduced Ejection Fraction in the Netherlands. Value in Health. doi:10.1016/j.jval.2017.05.013