2017-09-15
Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain–Barré syndrome in Bangladesh
Publication
Publication
Journal of Neuroimmunology , Volume 310 p. 46- 50
Guillain-Barré syndrome (GBS) is a post-infectious autoimmune polyneuropathy regulated by pro- and anti-inflammatory cytokines; TNFA polymorphisms may exert immune pathogenic roles in GBS. We assessed TNFA promoter region polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A) in Bangladeshi patients with GBS (n = 300) and healthy controls (n = 300) by PCR-RFLP and ASO-PCR. TNFA -863CA was significantly associated with GBS disease susceptibility (P = 0.0154) and disease severity (P = 0.0492). TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P = 0.0092) and -863AA associated with AMAN subtype of GBS (P = 0.0398). TNFA -863C/A may contribute to GBS severity and pathogenesis in Bangladeshi patients.
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| doi.org/10.1016/j.jneuroim.2017.06.005, hdl.handle.net/1765/100679 | |
| Journal of Neuroimmunology | |
| Organisation | Department of Medical Microbiology and Infectious Diseases |
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Jahan, I. (Israt), Ahammad, R.U. (Rijwan U.), Farzana, K.S. (Kaniz S.), Khalid, M.M. (Mir M.), Islam, M.B. (Mohammad B.), Rahman, M.I. (Mohammad I.), … Islam, Z. (2017). Tumor necrosis factor-alpha -863C/A polymorphism is associated with Guillain–Barré syndrome in Bangladesh. Journal of Neuroimmunology, 310, 46–50. doi:10.1016/j.jneuroim.2017.06.005 |
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