Growth, Growth Hormone Secretion, and GH Therapy in Children with Chronic Renal Failure or After Renal Transplantation

Growth is severely retarded in renal failure and there is usually little catch-up growth after renal transplantation. Many factors are involved in this growth retardation, among which the excess of insulin-like growth factor binding proteins 1 and 3 may play a prominent role. Growth hormone therapy leads to accelerated growth in the first years, and it appears likely that it will also increase final height. So far, growth hormone therapy appears to be safe with regard to kidney function.

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