How to: Establish and run a stool bank
Background: Since 2013, several stool banks have been developed following publications reporting on
clinical success of ‘faecal microbiota transplantation’ (FMT) for recurrent Clostridium difficile infections
(CDI). However, protocols for donor screening, faecal suspension preparation, and transfer of the faecal
suspension differ between countries and institutions. Moreover, no European consensus exists regarding
the legislative aspects of the faecal suspension product. Internationally standardized recommendations
about the above mentioned aspects have not yet been established.
Objective: In 2015, the Netherlands Donor Feces Bank (NDFB) was founded with the primary aim of providing a standardized product for the treatment of patients with recurrent CDI in the Netherlands. Standard operation procedures for donor recruitment, donor selection, donor screening, and production, storage, and distribution of frozen faecal suspensions for FMT were formulated.
Results and discussion: Our experience summarized in this review addresses current donor recruitment and screening, preparation of the faecal suspension, transfer of the faecal microbiota suspension, and the experiences and follow-up of the patients treated with donor faeces from the NDFB.
|Keywords||Clostridium difficile, Faecal microbiota transfer, Faecal microbiota transplantation, Faeces bank, Stool bank|
|Persistent URL||dx.doi.org/10.1016/j.cmi.2017.05.015, hdl.handle.net/1765/101007|
|Journal||Clinical Microbiology and Infection|
Terveer, E.M, van Beurden, Y.H, Goorhuis, A, Seegers, J.F.M.L, Bauer, M.P, van Nood, E, … Kuijper, E. (2017). How to: Establish and run a stool bank. Clinical Microbiology and Infection. doi:10.1016/j.cmi.2017.05.015